| Background |
Activin is the member of the TGF beta superfamily of cytokines. The current understanding of Activin A is classified as a hormone, a growth factor, and a cytokine. Depending on the different cell type, that overexpression of Activin A can either inhibit or promote cells division. There are important implications for tumor biology. Activin A also increase joint inflammation in rheumatoid arthritis (RA) and induces pathogenic mechanisms in the respiratory system. |
| Synonyms |
Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein |
| Uniprot ID |
P08476 |
| Molecular Weight |
The protein has a calculated MW of 12.96 kDa.
The protein migrates as 13-17 kDa under reducing condition (SDS-PAGE analysis). |
| Expression System |
Escherichia coli |
| Purity |
>97% as determined by SDS-PAGE analysis. |
| Activity |
Measure by its ability to inhibit the proliferation of mouse MPC-11 cells. The ED₅₀ for this effect is <10 ng/mL. The specific activity of recombinant human Activin A is approximately >1.0 x 10³ IU/mg. |
| Endotoxin Level |
<0.05 EU per 1 μg of the protein by the LAL method. |
| Protein Sequence |
GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS |
| Protein Tag |
Tag Free |
| Form |
Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4. |
| Application |
Cell Culture |
No references are available
