| 背景描述 |
Fas Ligand (FasL) is a 17.34 kDa tumor necrosis factor with 152 amino acid residues. FasL is mainly expressed from lymphoid tissue and secreted to blood. Binding to its receptor, TNFRSF6/FAS, leads to induce apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. |
| 别称 |
fas ligand, soluble Fas Ligand (sFasL), TNFSF6, CD95L, Apo I Ligand, APTL, APT1LG1, CD178, Fas-Lg, Tnfs, Tnlg1a, gld |
| 蛋白编码 |
P41047 |
| 分子量 |
The protein has a calculated MW of 18.27 kDa.
The protein migrates as 17-25 kDa under reducing condition (SDS-PAGE analysis). |
| 表达系统 |
Escherichia coli |
| 纯度 |
>98% as determined by SDS-PAGE. |
| 生物活性 |
Measure by its ability to induce apoptosis in Jurkat cells.
The ED₅₀ for this effect is <1 μg /mL. |
| 内毒素检测 |
<0.1 EU per 1 μg of the protein by the LAL method. |
| 蛋白序列 |
QIANPSTPSEKKEPRSVAHLTGNPHSRSIPLEWEDTYGTALISGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNQPLNHKVYMRNSKYPEDLVLMEEKRLNYCTTGQIWAHSSYLGAVFNLTSADHLYVNISQLSLINFEESKTFFGLYKL with polyhistidine tag at the N-terminus. |
| 蛋白标签 |
His Tag (N-term) |
| 产品形式 |
The protein was lyophilized from a 0.2 µm filtered solution containing 1X PBS, pH 8.0. If you have any concerns or special requirements, please confirm with us. |
| 产品应用 |
Cell Culture |
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