| Background |
CD28, a well-known costimulatory receptor expressed on T cells, is a type I transmembrane glycoprotein of the Ig superfamily. When the T cells receive the first signal delivered by APCs (antigen-presenting cells), it initiates signaling cascades, which favor T cell survival and proliferation. It has been demonstrated that patients with lung cancer who responded to PD-1 therapy had more CD28+ T cells, suggesting that CD28 may predict treatment response. |
| Synonyms |
TP44 |
| Uniprot ID |
P10747 |
| Molecular Weight |
The protein has a calculated MW of 28.61 kDa.
The protein migrates as 48-62 kDa under reducing condition (SDS-PAGE analysis). |
| Expression System |
HEK293 |
| Purity |
>95% as determined by SDS-PAGE. |
| Activity |
Testing in process |
| Endotoxin Level |
<0.1 EU per 1 μg of the protein by the LAL method. |
| Protein Sequence |
A DNA sequence encoding Human CD28 ECD (# P10⁷47) (Asn19 – Pro152) was expressed with polyhistidine-SUMO tag at the N-terminus. |
| Protein Tag |
His-SUMO Tag (N-term) |
| Form |
The protein was lyophilized from a 0.2 µm filtered solution containing 1X PBS, pH 7.4. If you have any concerns or special requirements, please confirm with us. |
| Application |
Cell Culture |
No references are available
