背景描述 |
Activin is the member of the TGF beta superfamily of cytokines. The current understanding of Activin A is classified as a hormone, a Growth Factors, and a cytokine. Depending on the different cell type, that overexpression of Activin A can either inhibit or promote cells division. There are important implications for tumor biology. Activin A also increase joint inflammation in rheumatoid arthritis (RA) and induces pathogenic mechanisms in the respiratory system. |
别称 |
Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein |
蛋白编码 |
P08476(Human), Q04998 (Mouse), P18331(Rat) |
分子量 |
The protein has a calculated MW of 13.1 kDa.
The protein migrates as 15 kDa under reducing condition (SDS-PAGE analysis). |
表达系统 |
Escherichia coli |
纯度 |
>95% as determined by SDS-PAGE. |
生物活性 |
Measure by its ability to inhibit the proliferation of mouse MPC-11 cells. The ED₅₀ for this effect is <10 ng/mL. The specific activity of recombinant human Activin A is approximately >1.0 x 10³ IU/mg. |
内毒素检测 |
<0.1 EU per 1 μg of the protein by the LAL method. |
蛋白序列 |
GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS |
蛋白标签 |
Tag Free |
产品形式 |
The protein was lyophilized from a 0.2 µm filtered solution containing 0.1M Glycine, 150mM NaCl, pH 4.0. If you have any concerns or special requirements, please confirm with us. |
产品应用 |
Cell Culture |