背景描述 |
4-1BB ligand (4-1BBL) is a type II transmembrane protein that is part of the tumor necrosis factor (TNF) ligand family. As an inducible co-stimulatory molecule, it presents on several antigen presenting cell (APC) types, including B cells, macrophages and DCs. The interactions between 4-1BB and 4-1BBL trigger pleiotropic effects on the immune response including antigen presenting process, proliferation of CD4 and CD8 positive T-cells, as well as cytokine secretion from T-cells through NFκB, c-Jun, and p38 downstream signal pathways activation.
Therefore, 4-1BB and 4-1BBL are recently used for the immunotherapy of cancer. |
别称 |
4-1BB ligand, CD137L, TNLG5A, TNFSF9, Tumor necrosis factor ligand superfamily member 9 |
蛋白编码 |
P41273 |
分子量 |
The protein has a calculated MW of 20.4 kDa.
The protein migrates as 20 kDa under reducing condition (SDS-PAGE analysis). |
表达系统 |
Escherichia coli |
纯度 |
>95% as determined by SDS-PAGE. |
生物活性 |
Measure by its ability to induce IL-8 secretion in human PBMCs. The ED₅₀ for this effect is 1-5 ng/mL. |
内毒素检测 |
<0.1 EU per 1 μg of the protein by the LAL method. |
蛋白序列 |
MREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLPSPRSE with polyhistidine tag at the C-terminus. |
蛋白标签 |
His Tag (C-term) |
产品形式 |
The protein was lyophilized from a 0.2 µm filtered solution containing 1X PBS, pH 7.4. If you have any concerns or special requirements, please confirm with us. |
产品应用 |
Cell Culture |