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3. 重组抗体/人源化抗体定制

Recombinant antibody production service（重组抗体定制）

♦ Key service features:

• Professional antibody sequence evaluation and optimization.
• Various constant region backbone choices.

   Human: IgG1

   Mouse: IgG2b

• Small scale expression test depends on your requirements.
• Flexible choice of antibody expression level of cell culture volume. (50 mL / 100 mL / 400 mL)

♦ Service workflow:

• Antibody sequence evaluation
• Choose the constant region backbone
• Gene synthesis and plasmid construction (VH-CH/VL-CL)
• Antibody expression and purification

♦ Sample requirements:

• Provide the sequence of antibody variable region

♦ Deliverables:

• Expression plasmid (Heavy chain and Light chain)
• Purified antibodies

Antibody humanization service（人源化抗体定制）

♦ Key service features:

• Our dedicated team will provide the most professional and attentive sequence prediction of the humanized antibody.
• We offer Biacore T200 service for clients that help you understand the binding affinity of your humanized antibody. (clients need to provide antigen)

♦ Service workflow:

• Clients need to provide the sequence of variable region.
• The gene structure of antibody VH and VL sequence will be analyzed by our experts.
• Chimeric antibody production, which contain mouse V region and human C region.
• Correct the sequence of humanized antibody with matching to human germline template.
• We will design and produce multiple candidates of humanized antibodies.
• We will pick up the best clone of these candidates depend on the test results (ELISA).

♦ Sample requirements:

• Sequence of variable region.
• Antigen for binding affinity analysis.

♦ Deliverables:

• Final report (including sequence analysis, results of binding affinity analysis result).
• Humanized antibody